3D model of a nerve terminal

«We used an integrative approach, combining quantitative immunoblotting and mass spectrometry to determine protein numbers; electron microscopy to measure organelle numbers, sizes, and positions; and super-resolution fluorescence microscopy to localize the proteins. Using these data, we generated a three-dimensional model of an “average” synapse, displaying 300,000 proteins in atomic detail.» Created by Burkhard Rammner: from Wilhelm, et al (2014). Science, 344: 1023-1028: