DNA Replication - Bruce Alberts (UCSF/Science Magazine)

Dr. Alberts has spent nearly 30 years trying to understand how DNA is replicated. When he began his graduate work in 1961, very little was known about how DNA was copied before each cell division. Alberts describes the key breakthroughs that led to our current understanding of the complex protein machine that drives DNA replication, and he provides some insight on tackling the big problems in biology.