For hemoglobin to function as an oxygen-carrier in the blood, it must have an equilibrium between the two main states of its quaternary structure, the unliganded “deoxy“ or “T state“ versus the liganded “oxy“ or “R state“. The unliganded (deoxy) form is called the “T“ (for “tense“) state because it contains extra stabilizing interactions between the subunits, specifically ionic interactions. In the high oxygen affinity R-state conformation, these ionic interactions are lost, and the tetramer is described as “relaxed“. In some organisms this difference is so pronounced that their Hb molecules dissociate into dimers in the oxygenated form. Structural changes that occur during this transition can illuminate how such changes result in important functional properties, such as cooperativity of oxygen binding and allosteric control by pH and anions.
#Tstate #hemoglobin #RState #protein #polypeptide #aminoAcid #deoxyhemoglobin
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