Feng Zhang Development and Applications of CRISPR Cas9 for Genome Editing

Watch on LabRoots at The Cas9 endonuclease from the microbial adaptive immune system CRISPR can be easily programmed to bind or cleave specific DNA sequence using a short RNA guide. Cas9 is enabling the generation of more realistic disease models and is broadening the number of genetically-tractable organisms that can be used to study a variety of biological processes. The Cas9 nuclease can also be modified to modulate transcription, alter epigenetic states,