“Breaking Barriers: The Total Synthesis of Palau’amine Explained“ (3D Visualization)
Dive into the world of advanced organic chemistry as we break down the total synthesis of Palau’amine, one of the most challenging targets for chemists. Discover how we overcame the obstacles presented by its complex structure, including its hexacyclic core and transazabicyclo[]octane substructure, through clear and engaging 3D animations.
🔬 In This Video:
A detailed walkthrough of the Palau’amine synthesis process.
Insights into the structural challenges and how they were addressed.
The innovative strategies and methodologies used to achieve total synthesis.
Whether you’re a student, a researcher, or just passionate about chemistry, this video will enhance your understanding of organic synthesis and inspire you with the breakthroughs in the field.
👉 Watch now and join us on this journey of scientific discovery! Don’t forget to like, comment, and subscribe for more cutting-edge chemistry content.
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Attributions:
Vector graphics in this video Designed by Freepik.
Source of the sound effects:
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References:
K. C. Nicolaou, Jason S. Chen. Classics in Total Synthesis III: Further Targets, Strategies, Methods. Wiley-VCH. 2011
Ian B. Seiple, Shun Su, Ian S. Young, Chad A. Lewis, Junichiro Yamaguchi, and Phil S. Baran. Angew. Chem. Int. , 49, 1095 –1098 #
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Time code:
00:00 - Intro
00:14 - Origin of The Name
00:34 - Unprecedented Structure
01:23 - Retrosynthetic Analysis
01:33 - Late Stage Synthetic Strategy
01:43 - Macro Palau’amine
03:10 - Forward Synthesis
03:14 - Diels-Alder Cycloaddition
03:27 - Endo Selectivity
03:40 - Azide Displacement
03:56 - Deprotection
04:08 - Reprotection
04:16 - Ozonolysis
04:27 - Enolization
04:35 - Regioselective Halogenation
04:45 - Intramolecular Aldol Reaction
04:54 - Selective Chlorination
05:28 - Elimination
05:45 - Luche Reduction
06:08 - Spirocylization
06:49 - Regioselevtive C-H Functionalization
07:00 - Instaling Non-Spiro Guanidine Moiety
07:15 - Installation of Pyrrole
08:07 - Final Step
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