Selena Gomez: Lupus

Selena Gomez: Lupus Most of us are pretty well aware about Selena Gomez’s struggle with lupus. Many people thought she went to rehab for a drug or alcohol addiction, but she was actually receiving treatment for lupus. The former Disney actress recently revealed that her surprise diagnosis was behind her hiatus from the spotlight. So, what exactly is lupus? Well, it’s an autoimmune disease (meaning the body’s immune system mistakenly attacks the body instead of only foreign particles). For people suffering from lupus, the immune system can affect any part of the body, but typically it affects the skin, joints, blood and kidneys. Gomez says, “I’ve discovered that anxiety, panic attacks and depression can be side effects of lupus, which can present their own challenges.” Toni Braxton and Nick Cannon also have lupus. In recent years, the genetic cause of lupus has been identified. It is a genetic mutation in a gene that usually repairs errors in DNA sequences which leads to the disease. In a new study, an international research team led by Drs. Carola Vinuesa from the Francis Crick Institute and Vicki Athanasopoulos at Australian National University sequenced the whole genome of a 7-year-old girl with a rare case of severe childhood lupus. Lupus is an autoimmune disease that can damage the skin, joints, heart, lungs, kidneys, and more. It’s about nine times more common in women than men. The study was funded in part by NIH’s National Human Genome Research Institute (NHGRI), National Heart Lung and Blood Institute (NHBLI), and National Institute of Neurological Disorders and Stroke (NINDS). The scientists pinpointed a mutation in a gene on the X chromosome, which women have two copies of, called TLR7. The protein encoded by this gene, TLR7, is an immune system protein that helps sense viruses by detecting a compound called guanosine. The mutation made TLR7 more sensitive to guanosine. Whole-genome sequencing of additional people with lupus uncovered two other mutations in TLR7 that seemed to have similar effects. The team thought that the altered TLR7 might trigger the immune system to attack normal tissues instead of viruses. When they engineered mice to have the abnormal version of TLR7, the mice developed symptoms of lupus and tissue damage similar to those in the girl who carried the gene. Immune cells isolated from these mice showed a greater response to guanosine compared to immune cells from normal mice. Further work found that extra activity of TLR7 led to certain types of immune system B cells surviving for longer than normal. B cells produce antibodies, including those involved in autoimmune attacks. Those that mistakenly identify normal tissues as a threat usually only live for a few days in the body. When the researchers engineered mice to have the abnormal TLR7 but lack a protein that TLR7 uses to control B cells, called MyD88, the mice didn’t develop lupus. This suggests that targeting TLR7 or proteins activated by it may help prevent or treat the disease. “While it may only be a small number of people with lupus who have variants in TLR7 itself, we do know that many patients have signs of overactivity in the TLR7 pathway,” says Dr. Nan Shen from the China Australia Center of Personalized Immunology, a member of the research team. “By confirming a causal link between the gene mutation and the disease, we can start to search for more effective treatments.” #NikolaysGeneticsLessons #selenaGomezOnKidneyTransplant #selenaGomezKidneyTransplant #selenaGomez #franciaRaisa #kidneyTransplant #selenaGomezLupus #lupus #selenaGomezSurgery #selenaGomezKindey #selenaGomezKidney #lupusAwareness #selenaGomezTransplant #whatIsLupus #whatExactlyIsLupus #theKimKardashianAndSelenaGomezDisease #kimKardashian #kimKardashianLupus #everyTimeItsNotLupusHouseMd #todayIFoundOut #deadliestDiseases