Actiunea se petrece in noiembrie 1923, in Berlinul lovit de saracie ca urmare a pierderii suferite in razboi. Abel Rosenberg este un acrobat evreu betiv si somer. Cand dupa o lunga perioada de depresie, Max, fratele lui Abel se sinucide, Abel impreuna cu fosta sa cumnata. Manuela, dansatoare de cabaret si prostituata de ocazie, se muta intr-un mic apartament langa clinica profesorului Hans Vergerus si sunt obligati de circumstante sa accepta oferta acestuia de a lucra in cadrul clinicii. In timp ce lucreaza aici, Abel descopera adevarul din spatele cercetarilor lui Vergerus si experimentele diabolice efectuate de acesta pe cobai umani, experimente comparabile cu cele efectuate in lagarele de concentrare naziste.
Filmul descrie tulburarile politice, brutalitatea nazista in crestere si decaderea morala generala a perioadei, in imagini foarte grafice.
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