Multi Scale Modeling of Chromatin and Nucleosomes

Strategic Programs for Innovative Research Field 1 Supercomputational Life Science Double-stranded DNA in which genetic information is encoded is folded into compact protein-DNA complex structures, called “chromatin“, in a nucleus of cell. When DNA is transcribed into RNA for gene expression, chromatin has to be in relaxed conformations. These conformational changes are regulated by chemical modifications of histones and so on. To study the complicated mechanism of life, thre