I did not complete whole Act 5 as solo Leper. I reached the boss with a full party, then modified the save file data this way:
1. Removed other 3 heroes.
2. Trinkets: Thrilling Tablet and Oversprung Pocketwatch.
3. Quirks: Bloodthirsty, Lurker and Deadly.
4. 5 memory buffs
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8 months ago 00:07:07 1
Solo Leper vs. Final Boss (Act 5)
2 years ago 00:00:56 1
Metallica - Leper Messiah - guitar solo lesson
2 years ago 00:19:59 1
[Darkest Dungeon 2] Solo Chad Leper vs ACT (5/5) FINAL BOSS [SPOILERS]
3 years ago 00:05:36 47
Metallica - Leper Messiah (NES-style w/ TE PO-33 cover)