How age-related beta cell changes contribute differently to insulin resistance versus prediabetes.
Artificial Intelligence Doctor -
This diagram illustrates how age-related beta cell changes contribute differently to insulin resistance versus prediabetes in elderly individuals. Let me explain the key differences:
a) In insulin resistance:
Beta cells initially compensate by increasing insulin production
This compensation can temporarily mask glucose elevation
The primary challenge is peripheral insulin resistance, not beta cell failure
b) In prediabetes:
Beta cell dysfunction becomes more prominent
Insufficient insulin secretion leads to noticeable glucose elevation
The transition to prediabetes occurs when beta cells can no longer compensate adequately
Interplay and progression:
The relationship between these conditions is dynamic:
a) Continuum:
Insulin resistance and prediabetes form a continuum in the progression towards type 2 diabetes
Age-related beta cell changes influence the rate of this progression
b)
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How age-related beta cell changes contribute differently to insulin resistance versus prediabetes.
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