Professional Mode for Resident Evil 4’s campaign can prove daunting for some. After the success of my Mercenaries guides, many people requested that I make a general guide for Pro mode.
In this video I will explain useful strategies and tricks for improving your gameplay, I will show the best ways to deal with each boss along with key fights against the regular enemies.
This video also contains the locations of all the treasures along with the shooting gallery challenges, to help with farming money for weapons and their respective upgrades.
Speaking of weapons, I also provide you with a weapon roadmap for what you should and shouldn’t upgrade based on your preferences.
This guide is not exhaustive and will not cover every single fight in the game, but I hope it explains everything well enough to help those who are struggling and perhaps teach a couple new things some players may not know about.
Below are the time-stamps of key moments so you can jump to whichever part you need, though I do recommend watching the whole guide.
00:00 - Introduction
02:10 - First Village Fight
06:36 - Canyon Fight
13:00 - Del Lago Fight
15:15 - El Gigante Fight
18:20 - Cabin Fight
19:36 - 2nd Gigante Fight
20:20 - Chainsaw Sisters Fight
22:15 - Chief Mendez Boss Fight
24:50 - The Castle
26:21 - Sword Room
28:05 - Garrador Fight
28:55 - Water Room Fight
30:53 - Shooting Gallery A
32:13 - Novistadores 1
35:53 - Praying Cultists
37:18 - Minigun Zealot
39:26 - Salazar Ambush
40:20 - The Maze
42:50 - Garrador Cage
44:16 - Ashley’s Escape
45:41 - Backtrack for Broken Butterfly
46:47 - Lava Room
47:54 - Shooting Gallery B
48:33 - Knights
50:57 - Novistadores 2
54:27 - Double Garrador
56:18 - Verdugo Boss Fight
56:52 - Shooting Gallery C
57:48 - The Mines
59:44 - Two Gigantes
01:01:05 - Novistadores 3 (Caves)
01:02:55 - Mines 2
01:06:03 - Minecart Fight
01:08:07 - Salazar Statue
01:10:23 - Castle Tower
01:11:21 - Salazar Boss Fight
01:12:28 - The Island
01:12:46 - First JJ
01:17:17 - Shooting Gallery D
01:18:52 - Regenerators 1
01:20:14 - Thermal Scope
01:21:45 - Iron Maiden
01:23:10 - Wrecking Ball Room
01:24:15 - Regenerators 2
01:24:25 - Demolition Truck
01:25:59 - It Boss Fight
01:31:27 - Krauser Boss Fight
01:33:30 - Mike (Helicopter) Battles
01:38:58 - Final Regenerator
01:39:39 - Third JJ & Final Ganado Assault
01:43:23 - Saddler Boss Fight
01:47:05 - Closing Remarks & Shoutouts
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