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The Effects of HemoHim on the Immune System Professor Jinhan Kang 강진한 교수 Senior Professor of Pediatric Infections, Vaccine and Bio Research Institute, Catholic Medical University Professor Emeritus, Department of Pediatrics, Catholic Medical University Chairman of the Korean Vaccine Society Vaccine Activation Committee Currently, the 20th director of the Korea Federation of Science and Technology Societies (KIST) HemoHim has 18 articles in SCI (Science Citation Index) Radiation damage prevention and recovery effect, Immune effect of HemoHIM against irradiation, Radiation field damage prevention effect by HemoHIM, Protective effects of HemoHIM on immunity and hematopoietic stem cell system after gamma irradiation, Immune and Hematopoietic Systems Against Irradiation, After gamma irradiation in the HemoHIM administration group 1) The effect of blocking apoptosis of bone marrow cells, 2) check the activation of immune cells in the spleen; 3) B lymphocytes, lymphocytes and natural killer cells (NK cells) Confirmation of increase in HemoHIM administration group (HemoHIM Ameliorates the Persistent Down-Regulation of Th1-like Immune Responses in Fractionated y-Irradiated Mice by Modulating the IL-12p70-STAT4 Signaling Pathway) (Protective Effect of an Herbal Preparation (HemoHIM) on Radiation-Induced Intestinal Injury in Mice) As a result, radiotherapy in cancer patients HemoHIM will help block side effects and speed recovery Combination treatment effect of anticancer drugs Combination effect of HemoHIM and chemotherapy in the treatment of melanoma (Synergistic Anti-cancer Activity of MiH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice) For the treatment of melanoma, a malignant tumor of the skin Results of combined treatment with cisplatin and hemohim, anticancer drugs 1) NK cell activity 2) IL-2 and gamma interferon were elevated, confirming an improved effect compared to the case of treatment with anticancer drugs alone 3) Confirm the result of less damage to liver function and kidney function As a result, anticancer drug combination treatment is expected to have improved effects and fewer side effects than anticancer drug alone treatment. Anticancer drug combination treatment effect Anticancer drug Cisplatin immunosuppressive preventive effect Anticancer drug agonist effect of HemoHIM in the treatment of melanoma (Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression) (Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice) anti-inflammatory effect (Effect of relieving respiratory inflammation by HemoHIM) HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide anti-inflammatory effect Effect of HemoHIM on preventing gastric mucosal inflammation damage Preventive effect of allergic respiratory mucosal inflammation according to T-lymphocyte cell response regulation Artificial respiratory inflammation induced in animal experiments Analysis of bronchoalveolar fluid in animals treated with HemoHIM Relieves mucosal inflammation by lowering levels of inflammatory substances (, (IL)-6, ) (Protective effects of a standardized extract (HemoHIM) using indomethacin-and ethanol/HCl-induced gastric mucosal injury models) (Preventative Effect of an Herbal Preparation (HemoHIM) on Development of Airway Inflammation in Mice via Modulation of Th1/2 Cells Differentiation) Immunomodulatory effect Anti-diabetic effect by immunomodulation (Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation [HemoHIM] on Streptozotocin-induced Diabetic Mice) Normal insulin secretion by restoring the immune function of pancreatic-cells in the pancreas Bone Marrow Origin of HemoHIM Mastoid cell immunity enhancement and regulatory effect (Herbal preparation (Hemo-HIM) enhanced functional maturation of bone marrow derived dendritic cells mediated toll-like receptor 4) Nondiabetic HM Diabetic Hem Recently, research results have been continuously published that complex sugar substances and glycan substances contained in herbal medicinal plants activate immune cells that effectively block or remove cancer cells. HemoHIM also activates bone marrow-derived mastoid (dendritic) innate immune cells, confirming that immunity is enhanced and regulated. Summary of immune effect study results 1 Expected effect of maintaining immune function at an advanced age according to the activation of residual innate immune cells 2 Prevention of radiation exposure damage and fast recovery expectation 3 Combined cooperation effect and side effect reduction expected effect by concurrent anticancer drug treatment 4 Expected anti-inflammatory and anti-allergic effects of the respiratory tract and intestinal mucosa 5 Expect immune enhancement and regulation effect by activating bone marrow-derived innate immune cells