What is DNA consensus sequence?

Watch my second video on the topic “How to Understand Sequence Logos“ Here is my another video about DNA Consensus Sequence: In molecular biology and bioinformatics, the consensus sequence is the calculated order of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment. It represents the results of a multiple sequence alignments in which related sequences are compared to each other and similar sequence motifs are calculated. Such information is important when considering sequence dependent enzymes such as RNA polymerase. Developing software for pattern recognition is a major topic in genetics, molecular biology, and bioinformatics. Specific sequence motifs can function as regulatory sequences controlling biosynthesis, or as signal sequences that direct a molecule to a specific site within the cell or regulate its maturation. Since the regulatory function of these sequences is important, they are thought to be conserved across long periods of evolution. In some cases, evolutionary relatedness can be estimated by the amount of conservation of these sites. Notation The conserved sequence motifs are called consensus sequences and they show which residues are conserved and which residues are variable. Consider the following example DNA sequence: A[CT]N{A}YR In this notation, A means that an A is always found in that position; [CT] stands for either C or T; N stands for any base; and {A} means any base except A. Y represents any pyrimidine, and R indicates any purine. In this example, the notation [CT] does not give any indication of the relative frequency of C or T occurring at that position. An alternative method of representing a consensus sequence uses a sequence logo. This is a graphical representation of the consensus sequence, in which the size of a symbol is related to the frequency that a given nucleotide (or amino acid) occurs at a certain position. In sequence logos the more conserved the residue, the larger the symbol for that residue is drawn, the less frequent, the smaller the symbol. Sequence logos can be generated using WebLogo, or using the Gestalt Workbench, a publicly available visualization tool written by Gustavo Glusman at the Institute for Systems Biology. #Nucleotide #Cancer #23andme #sequenceLogo #aminoAcid #bioinformatics #Iherb #sequenceMotifs #GeneticTesting #Genetics #consensusSequence #regulatorySequences #molecularBiology #GeneticsLecture #NucleicAcidSequence #DNAChemicalCompound #bioinformaticsForBeginners #bioinformaticsCourse #whatIsBioinformatics #sequenceAlignmentInBioinformatics #biologicalDatabasesInBioinformatics #bioinformaticsLecture #genbankInBioinformatics #introductionToBioinformatics