How to solve H-W problems

Hardy, Weinberg, and the population geneticists who followed them came to understand that evolution will not occur in a population if seven conditions are met: 1. mutation is not occurring 2. natural selection is not occurring 3. the population is infinitely large 4. all members of the population breed 5. all mating is totally random 6. everyone produces the same number of offspring 7. there is no migration in or out of the population These conditions are the absence of the things that can cause evolution. In other words, if no mechanisms of evolution are acting on a population, evolution will not occur--the gene pool frequencies will remain unchanged. However, since it is highly unlikely that any of these seven conditions, let alone all of them, will happen in the real world, evolution is the inevitable result. Godfrey Hardy and Wilhelm Weinberg went on to develop a simple equation that can be used to discover the probable genotype frequencies in a population and to track their changes from one generation to another. This has become known as the Hardy-Weinberg equilibrium equation. In this equation (p² 2pq q² = 1), p is defined as the frequency of the dominant allele and q as the frequency of the recessive allele for a trait controlled by a pair of alleles (A and a). In other words, p equals all of the alleles in individuals who are homozygous dominant (AA) and half of the alleles in people who are heterozygous (Aa) for this trait in a population. In mathematical terms, this is p = AA ½Aa Likewise, q equals all of the alleles in individuals who are homozygous recessive (aa) and the other half of the alleles in people who are heterozygous (Aa). q = aa ½Aa Because there are only two alleles in this case, the frequency of one plus the frequency of the other must equal 100%, which is to say p q = 1 Since this is logically true, then the following must also be correct: p = 1 - q There were only a few short steps from this knowledge for Hardy and Weinberg to realize that the chances of all possible combinations of alleles occurring randomly is (p q)² = 1 or more simply p² 2pq q² = 1 In this equation, p² is the predicted frequency of homozygous dominant (AA) people in a population, 2pq is the predicted frequency of heterozygous (Aa) people, and q² is the predicted frequency of homozygous recessive (aa) ones. From observations of phenotypes, it is usually only possible to know the frequency of homozygous recessive people, or q² in the equation, since they will not have the dominant trait. Those who express the trait in their phenotype could be either homozygous dominant (p²) or heterozygous (2pq). The Hardy-Weinberg equation allows us to predict which ones they are. Since p = 1 - q and q is known, it is possible to calculate p as well. Knowing p and q, it is a simple matter to plug these values into the Hardy-Weinberg equation (p² 2pq q² = 1). This then provides the predicted frequencies of all three genotypes for the selected trait within the population. #Hardy #Weinberg #PopulationGeneticists #mutation #naturalSelection #phenotypes #Genetics #genotypes