NEW STUDY: Oreos Lower LDL Cholesterol!

Paper link: **Call to action** - HELP US promote this line of research by COPYING THE ABOVE LINK and including it in a post to social media, especially Twitter... I’ll also be highlighting the best takes in the coming week ;) 0:00 – Intro 0:28 – metabolic demonstration 0:43 – Part I, the idea 1:30 – LMHR triad 1:58 – Lipid Energy Model 3:06 – Part II, the experimental design 4:19 – Part III, results 6:00 – results summary 6:40 – Part IV, What’s Next? 7:37 – Thanks and Call to Action Aim: To tested the prediction -- consistent with the Lipid Energy Model (below) -- that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDL-C levels by a similar, or greater, magnitude than high-intensity statin therapy. Findings: Oreo supplementation (12 cookies/d) lowered LDL-C by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDL-C by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as high-intensity statin therapy for LDL cholesterol lowering in this LMHR subject. The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It’s a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as ’productive provocation,’ a form of ’legit-bait’ that will hopefully help prompt discussions and larger-scale experiments that need to happen. 6 select Prior publications 1/ META of RCTs (new, 1/16/24) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: **LINK: ** VIDEO: 2/ n = 10 lean healthy women Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: LINK: VIDEO: 3/ JCL editorial Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi: Link: (22)00295-1/fulltext 4/ Lipid Energy Model Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022; doi: Link: Video: 5/ LMHR, first paper Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022; doi: Link: (22)00007-5/fulltext 6/ Low Sat Fat LMHR case report Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: Link: Video: