Severe combined immunodeficiency - A deadly combination of defects of T & B lymphocytes Natural killer cells
Its a primary immunodeficiency (inherited in the family) affecting T lymphoocytes, B lymphocytes and Natural killer cells in different combinations.
These children die within one year without a bone marrow have been cases like “David the bubble boy“ who survived for 12 years in a sterile chamber isolated from pathogens.
Patients are small babies that suffers from fungal, bacterial, or viral infections since their immune system is not functioning as it should.
The symptoms can be:
recurrent infections resistant to antibiotics,
failure to thrive with abnormal growth curves,
diarrhea,
diaper rash,
bronchitis,
pneumonia,
otitis media,
liver abscess,
morbilliform rash,
oral candidiasis
Doctors can check the sequence of DNA to determine any mutations that would cause this disease.
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