Invariant natural killer T cells coordinate removal of senescent cells

Full article: (21)00163-X Authors: Arora et al. Affiliation: Diabetes Center, University of California, San Francisco, CA, USA Video: Anil Bhushan, PhD Summary: The failure of immune surveillance to remove senescent cells drives age-related diseases. Here, the authors target an endogenous immune surveillance mechanism that can promote elimination of senescent cells and reverse disease progression. The results uncover a senolytic capacity of tissue-resident iNKT cells and pave the way for anti-senescence therapies that target these cells and their mechanism of activation.