The molecular force sensor titin kinase

Our muscles get stronger after excercise, but how do they sense where and when to grow? In combination with AFM-based single molecule force spectroscopy, molecular dynamics simulations and enzymatics we showed, that the autoinhibited muscle enzyme titin kinase gets activated by physiological forces and can act as a force sensor regulating gene expression and protein turnover. - The 3D animation shows a zoom inside the muscle up to the smales protein building blocks to visualize how co