The mermaid syndrome (sirenomelia) is an extremely rare anomaly, an incidence of 1 in 100,000 births, in which a newborn born with legs joined together featuring a mermaid-like appearance (head and trunk like humans and tail like fish), and in most cases die shortly after birth.
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Sirenomelia is a rare and fatal congenital defect characterized by varying degrees of lower limb fusion, thoracolumbar spinal anomalies, sacrococcygeal agenesis, genitourinary, and anorectal atresia.
[1] The incidence of sirenomelia is case/100,000 births with male to female ratio being 3:1.
[2] The rarity of the case is obvious from the fact that many a gynecologist might not have come across a case of sirenomelia in their whole professional carrier. There is a strong association with maternal diabetes where relative risk is 1:200-250 and up to 22% of fetuses with this anomaly will have mothers with diabetes.
[3,4] We report two cases of sirenomelia where maternal drug abuse and overt diabetes may have been the cause of this rare anomaly.
Hyperthermia and amniotic band disruption are the underlying causes of the occurrence of the mermaid syndrome. The exposure to teratogenic factors, such as air pollution, and mother-to-drug contact with cocaine and tobacco and alcohol cigarettes, and radionuclide are also among the causes
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