Nonsense mutation

A nonsense mutation is called “nonsense“ because it results in a premature stop codon within the mRNA sequence, effectively truncating the translation process of the mRNA into a protein. This type of mutation introduces a “stop“ signal in the middle of the coding sequence, where normally amino acids would be added to the growing polypeptide chain. As a result, the translation machinery stops early, leading to the production of a shortened, and usually nonfunctional, protein. The term “nonsense“ reflects the fact that this premature stop codon does not correspond to any of the usual amino acids and thus makes no “sense“ in the context of encoding a complete protein. It’s a mutation that disrupts the normal flow of genetic information from DNA to functional protein, often resulting in a loss of function of the protein product. Problem: A nonsense mutation is one that: A) Changes an amino acid from one to another B) Deletes segments of RNA C) Adds an additional codon to an RNA transcript D) Creates a premature stop codon