Total Synthesis of Hypersampsone M

An organic chemistry minilecture on the ’Total Synthesis of Hypersampsone M’ by Adrian E. Samkian, Scott C. Virgil,* and Brian M. Stoltz*. It features an innovative ring expansion rearrangement, zincate addition-annulation and an aldol cyclization-lactonization sequence. SUPPORT THE CHANNEL ON PATREON: NMR Spectroscopy in music: J. New Music Res. 2021, 50:5, 487-501 Socials: References: J. Am. Chem. Soc. 2024, 146, 28, 18886–18891 (This work) . 2014, 16, 3448−3451 (Discovery) J. Am. Chem. Soc. 2017, 139, 6, 2484–2503 (HAT Coupling) Synthesis 1978, 1978, 150−152 (Annulation) Org. Lett. 2012, 14, 1, 214–217 (Amidation) Synlett 2011, 14, 20722074 (Amidation)