Sodium Regulation: Proximal Convoluted Tubule

This lesson explores how sodium is regulated along the proximal convoluted tubule (PCT). It focuses on the transcellular and paracellular pathways, driving forces, the role of the sodium-cotransporters and the sodium/hydrogen exchanger (NHE3), and carbonic anhydrase. It also discusses how acetazolamide acts as a diuretic by inhibiting NHE3-dependent sodium reabsorption. For help preparing for an exam on this and other topics, visit