Sodium Regulation: Thick Ascending Limb

This lesson explores how sodium is regulated along the thick ascending limb (TAL). In particular, the role of the sodium, potassium, 2 chloride cotransporter (NKCC2), the sodium/hydrogen exchanger (NHE3), the paracellular pathway, driving forces, and how genetic mutations and loop diuretics affect sodium reabsorption. For help preparing for an exam on this and other topics, visit